Postdoctoral Research Fellow - Reinherz Lab

The Reinherz lab at Dana-Farber Cancer Institute and Harvard Medical School is recruiting a postdoctoral fellow to study HIV-1 vaccine immunology. We use an interdisciplinary approach combining structural biology, molecular biology, biochemistry, and immunology to generate insights that can be translated into HIV-1 vaccine design.

Specific research areas of interest include molecular and cellular mechanisms underlying B cell immunodominance and strategies to modulate B cell affinity maturation during vaccination to induce protective immunity while preventing induction of autoimmunity. The laboratory provides a rich training environment and access to cutting-edge techniques.

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS, and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations.

We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

Position Summary

Conduct research focused on   HIV-1 Env vaccine development   and the   modulation of B cell affinity maturation .

Contribute to   structure-guided immunogen design   and the development of   novel vaccine strategies   to improve subdominant antibody responses.

Work in a collaborative research environment while independently driving experimental projects.

Key Responsibilities

• Design and execute studies related to   HIV-1 Env vaccine candidates .
• Investigate approaches to enhance   B cell affinity maturation   and antibody responses.
• Perform   mouse immunization studies   and related in vivo experimental work.
• Analyze   immune sera   to assess vaccine-elicited responses.
• Conduct   flow cytometry (FACS)   for immune cell characterization and analysis.
• Perform   B cell repertoire analysis   and   immunohistology   experiments.
• Carry out   molecular cloning ,   protein expression , and   protein purification .
• Maintain and utilize   cell culture systems   to support research activities.
• Interpret experimental data, prepare reports, and contribute to manuscripts for publication.
• Collaborate effectively with other lab members and support broader research goals.
• Required Qualifications
• Recent   PhD   or   MD/PhD   in   biomedical sciences   or a closely related field.
• Strong background in   immunology ,   molecular biology , and   biochemistry .
• Hands-on experience with techniques used to evaluate immune responses, including: Antibody measurement
• B cell and T cell response analysis
• B cell repertoire analysis
• Mouse models and animal handling
• Demonstrated publication record in   peer-reviewed journals .
• Excellent   written and verbal communication skills .
• Ability to work   independently   as well as collaboratively in a team setting.

Preferred Qualifications

• Experience with   molecular cloning   and related molecular biology techniques.
• Proficiency in   protein expression ,   protein purification , and   biochemical methods .
• Experience with   cell culture   techniques.
• Strong organizational skills and the ability to manage multiple projects.
• Application Materials
• Applicants should submit: A   CV
• A brief   statement of research interests/goals
• Three professional references
• At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are committed to having faculty and staff who offer multifaceted experiences. Cancer knows no boundaries and when it comes to hiring the most dedicated and compassionate professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply.
• Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law.
• EEO Poster
• . Pay Transparency Statement
• The hiring range is based on market pay structures, with individual salaries determined by factors such as business needs, market conditions, internal equity, and based on the candidate’s relevant experience, skills and qualifications.

For union positions, the pay range is determined by the Collective Bargaining Agreement (CBA).

$72,000.00 - $76,385.00