Postdoctoral Fellow – Imaging Technology and Compound Screening, Regev & Singh Labs

A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That’s what makes us Genentech.

A Postdoctoral Fellow position is available for a highly motivated and independent scientist to pioneer high-throughput platforms that reveal compound effects across diverse model systems and accelerate the path from molecule to medicine. The vision for this role is to push image-based profiling well beyond what is possible today—developing the experimental and computational methods to capture far richer measurements of cellular state and to extend compound screening across a much broader range of model systems than is currently

feasible.

This is a hands-on position for a scientist who is energized by developing new assays at the bench and who is just as drawn to reasoning about the analytical and AI  methods needed to interpret the resulting data. You will join a collaborative, cross-disciplinary environment and will have the opportunity to contribute to high-impact scientific publications.

The Opportunity:

High-Plex Assay Development: Develop and optimize high-plex imaging assays that capture rich, multiplexed readouts of cell state and morphology.

Computational Methods: Develop computational approaches that expand the information extracted from each sample and improve the efficiency and quality of imaging-based measurements.

Large-Scale Screening: Design and execute large-scale compound screens across diverse, disease-relevant model systems, generating systematic, multimodal readouts of cellular response.

Data-Driven Discovery: Apply single-cell and multi-omics style analyses to build maps of perturbation relationships and to prioritize the most promising compounds for a given function or activity.

Automation & Scale: Leverage laboratory automation and high-throughput workflows to iteratively design, run, and learn from screens at scale.

Collaborative Research: Collaborate productively with experimental and computational scientists across departments, present your work to project teams, and contribute to high-impact scientific publications.

Professional Development: Join the Genentech postdoctoral training program, which provides an outstanding environment and the opportunity to pursue fundamental scientific questions while building methods that drive breakthrough discoveries in drug development.

Who You Are:

Ph.D. with a proven track record of excellence in single-cell genomics, imaging, bioengineering, biophysics, quantitative biology, or a related field, with hands-on experimental expertise.

Must have advanced at least one key research project as evidenced by a first-author paper published or accepted in a leading peer-reviewed journal.

Strong hands-on experience in microscopy and quantitative imaging; experience with multiplexed, high-content, or optical pooled screening approaches is a plus.

Computational expertise spanning image analysis and machine learning, with a track record of developing or adapting methods and programming fluently in Python or a comparable language.

Independent scientist with outstanding communication skills, a strong passion and commitment to science, who works well within a team.

Excited about building new methods to screen compounds at scale and to discover what drives cellular function and activity.

Preferred Qualifications:

• Experience developing or deploying multiplexed imaging assays.
• Experience with AI/ML applied to imaging or other high-dimensional biological data.
• Experience with laboratory automation, liquid handling, and high-throughput experimental workflows.
• Experience analyzing large-scale perturbation datasets and integrating multimodal data..
• Postdoc Program
• Elevate your research career to new heights with Genentech’s Postdoctoral Program! Join a prestigious community of early career scientists and kick-start your journey to becoming a scientific leader in biotechnology and bioengineering. With competitive salaries and fully funded research expenses, you can dedicate yourself to groundbreaking research aligned with Genentech’s strategic ambitions.
• The postdoc program is designed to empower recent Ph.D. graduates to conduct world-class research, publish in top-tier journals, and build a robust scientific network. Throughout the program you will receive the mentorship and support necessary to develop into an independent scientist and leader.
• The Genentech Postdoc Program (http://careers.gene.com/us/en/students-postdocs) provides access to world-class seminars, professional development workshops, and networking opportunities. Apply now to the Genentech Postdoctoral Program and unlock your full potential!

The expected salary range for this position based on the primary location of South San Francisco, California is $100,000 to $106,500. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. This position also qualifies for the benefits detailed at the link provided below.