Vice President, Immunology Research - Genentech Research & Early Development

Immunology is one of Genentech/Roche’s five core therapeutic areas of focus, alongside Oncology, Cardiovascular Renal & Metabolism (CVRM), Ophthalmology and Neurology. Breakthroughs in our understanding of human disease, propelled by the development of pathobiology maps, foundational disease models and the integration of artificial intelligence combined with the rapid evolution of computationally assisted drug discovery and therapeutic modalities have unlocked unprecedented opportunities to deliver life-changing medicines for

patients. As we enter a new era of target identification and drug development, the potential to discover and develop transformative therapies has never been greater.

ROLE OVERVIEW AND KEY ACCOUNTABILITIES

The VP of Immunology Research will oversee an organization of ~70 researchers and will be responsible for the following critical accountabilities:

• Shaping and executing our Immunology research strategy to maximize impact
• Cultivate an innovative, dynamic and intellectually rigorous environment that inspires groundbreaking discoveries
• Seamless collaboration with Drug Discovery to leverage existing and explore novel drug modalities to target key pathogenic pathways underlying human disease

Driving cross-disciplinary research at the interface of immunology and inflammation across multiple therapeutic areas, including:

• Neuroscience: focus on neuroimmune strategies to address neurologic diseases
• Oncology: enhance understanding to leverage innate immune, adaptive immune and stromal mechanisms for treating hematologic and solid malignancies
• Cardiovascular, Renal & Metabolism (CVRM): discover and develop novel therapies targeting the innate and adaptive immune system across a broad range of diseases in this space, including obesity, atherosclerotic cardiovascular disease, heart failure, and kidney disease
• Ophthalmology: focus on immunomodulatory approaches for the treatment of eye diseases
• Infectious Diseases: investigate the role of the microbiome and host-pathogen interactions in autoimmune and inflammatory diseases; advancing discovery and development of innovative antibacterial and antiviral therapeutics to support Roche’s goals in global health security
• Partnering with Corporate Business Development to identify strategic external partnerships around the globe that support our strategy and strengthen the portfolio to create long-term value for the enterprise
• Collaborating with the Translational Medicine organization to deepen insights into human disease heterogeneity, enabling the discovery and development of biomarkers to guide precision medicines and identification of novel targets/pathways through ‘reverse translation’ from the clinic
• Partnering with the Center of Excellence in Computational Sciences to incorporate advanced computational approaches and artificial intelligence for novel target discovery/validation and drug discovery and development
• Advancing functional genomics efforts in collaboration with our Translational Genomics and Proteomics Center through interrogation of normal and human disease tissues and conducting large scale genomic and small molecule screens to identify novel therapeutic targets and leads, respectively
• Working with Early Clinical Development to translate novel biological insights into therapeutic strategies aimed at specific diseases and patient segments
• Represent Genentech/Roche externally at scientific conferences and meetings
• Manage budgets, resources, and timelines effectively to ensure the successful execution of research programs
• Ensure all research activities comply with relevant regulatory requirements and ethical standards
• This individual will ensure seamless cross-functional collaboration while advancing innovative science that transforms the lives of patients
• The VP of Immunology Research will report to the Senior Vice President, Research-Biology in gRED Research, an independent R&D division in the Roche group. The leader will be a:
• Member of Research Review Committee
• Member of the gRED Research Leadership Team
• Ad-hoc member of the Early Stage Portfolio Team
• Ad-hoc member of teams that are formed to evaluate external innovation and business development opportunities
• Contribute to appropriate governance bodies to establish strategic directions and deliver critical objectives across the entire organization to improve efficiency and accelerate product development
• LEADERSHIP OBJECTIVES FOR THIS ROLE

Team Leadership, Attracting Talent and Developing People: Fosters high-performing culture via VACC Leadership, sets clear goals and drives accountability. Breaks silos, empowers, attracts top talent, and guides leaders and teams through creative tensions

Creates holistic vision: Holistically envisions and co-creates an impactful, resonant vision for the enterprise, skillfully communicates and inspires teams, defines excellence, and leads directly and influentially, fostering a high-performance environment

Builds strategy: Healthcare-savvy with a profound grasp of Roche's vision, portfolio, and organizational constraints, adept at crafting impactful strategies that bridge business realities. Understands how to shape the ecosystem to benefit the Group without over-complication

Acts as a Subject Matter Expert: Possesses depth & breadth of expertise in the subject domain. Able to shift between the need to provide granular & deep technical expertise vs contextualize and share information towards the non-experts

Partners with the business: Leveraging their expertise, actively contributes within and beyond their domain, fostering fruitful breakthroughs and demonstrating a holistic understanding of group opportunities and challenges

Demonstrates potential: Actively demonstrates high levels of critical thinking / intellectual strength and learning agility (curiosity, tolerance to ambiguity and proactivity). Demonstrates the behavioral competencies that underpin emotional intelligence (self-awareness, empathy and open-mindedness)

WHO YOU ARE

Qualifications and Experience:

• PhD, MD, MD / PhD or equivalent advanced degree
• Proven leader with a minimum of 10 years of experience (prefer 15 years), including > 5 years at the Director or equivalent level or above
• Outstanding track record of scientific accomplishments spanning the field as demonstrated through scientific publications, presentations and/or patents
• Critical thinker with ability to analyze possibilities, solutions, and development of pragmatic solutions, as well as a “big picture” innovator
• Strong, lucid and influential communicator: exceptional influencing skills that demonstrate strong thought partnership and create effective relationships with internal and external stakeholders
• Demonstrated leadership and action to foster a supportive and inclusive environment
• Excellent collaboration skills and ability to build and connect strong teams and communities
• Record of developing and mentoring excellent scientific leaders
• LOCATION
• This position is based in South San Francisco, CA
• Relocation assistance is available

The expected salary range for this position based on the primary location of South San Francisco, CA is $424,150 - $523,950.  Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law.  A discretionary annual bonus may be available based on individual and Company performance.  This position also qualifies for the benefits detailed at the link provided below.

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