Research Postdoctoral Fellow-Tong Lab

SHIFT:

Any (United States of America)

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A Brief Overview

Under the direction/guidance of a mentor (principal investigator), assumes responsibility for a specific, on-going research project. The experience will serve to extend, refine and enhance skills necessary for professional and career development, and will enable the individual to broaden his/her scientific background by acquiring new research capabilities. It is expected that this individual will conduct independent scholarly research, and will contribute directly to the overall research goals of the project and the research group.

This role will be expected to participate in project planning, recording and interpretation/evaluation of data, and communication of results. This position will also be expected to acquire technical, lab management, and manuscript/grant writing skills; and participate in seminars, lectures, poster sessions and presentations at national meetings. This role also may be required to supervise junior lab members, develop new methods and protocols for research, and assist with the development of other research projects in the lab.

CRISPR screens in hematopoietic stem cells to study DNA repair and DNA replication

A postdoctoral fellow position is available at the University of Pennsylvania School of Medicine and the Children's Hospital of Philadelphia to perform state-of-the-art CRISPR/Cas9 screens to identify novel therapeutic targets for treating hematopoietic stem cell diseases. Dr. Tong’s laboratory studies cytokine receptor signaling in replication stress , DNA repair , and ubiquitin signaling in hematopoietic stem cells , bone marrow failure , and leukemia .

Hematopoietic stem cells give rise to all circulating blood cells throughout life. Maintenance of stem cell self-renewal, proliferation, and differentiation is regulated by complex signaling pathways. Aberrant regulation leads to bone marrow failure or leukemia. Genome integrity plays a critical role in blood development and the prevention of leukemia and ageing.

This postdoctoral fellow position will focus on studying the mechanisms that safeguard the genome during DNA replication and investigating how failures in these processes impact hematopoietic stem cell function, which leads to bone marrow failure and/or leukemia. CRISPR screens with our expert collaborators will delineate a new understanding of stem cell fitness upon replication stress and point to potentially druggable pathways for intervention in the treatment of diseases with stem cell dysregulation.

Our recent publications include:

• Cell Stem Cell , 28(7):1275-1290, 2021; Journal of Clinical Investigation 136(1): e191713, 2026; Blood 138(22):2244-2255, 2021; Blood 133(14): 1560-1571, Apr 2019.

Nature communications 9(1): 3915, Sep 2018; Genes & developm ent 31(10): 1007-1023, May 2017; You can find more of our recent publications and laboratory information in below website. https://www.med.upenn.edu/apps/faculty/index.php/g275/p8146029

What you will do

• Conduct independent scholarly research and develop new methods and protocols
• Participate in project planning, recording and evaluation of data
• Acquire technical, lab management and grant writing skills
• Participate in seminars, lectures, poster sessions and presentation at national meetings
• Supervise junior lab members
• Assist with other research projects
• Education Qualifications
• Doctorate Required
• Skills and Abilities
• Ability to wear a respirator device
• To carry out its mission, CHOP is committed to supporting the health of our patients, families, workforce, and global community. As a condition of employment, CHOP employees who work in patient care buildings or who have patient facing responsibilities must receive an annual influenza vaccine. Learn more.
• EEO / VEVRAA Federal Contractor | Tobacco Statement