Postdoctoral Associate | Laboratory of Genetically Encoded Small Molecules

Organization Overview

Researchers in the Laboratory of Genetically Encoded Small Molecules are working on projects related to the human microbiome, bacterial small molecules, and host-microbial interactions. The lab's research is focused on identifying bacterial genes, pathways, and molecules that influence host-cellular functions and developing these host-microbial interactions into novel treatments for human disease.

To this end, we focus on three major areas of research: 1) high throughput screening of bacterial metabolites and genes to identify effector functions, 2) mouse models of inflammatory and metabolic diseases, and 3) in vivo validation of bacterial metabolites and genes in human cohorts.

Overview

The Postdoctoral Associate will use methods from molecular biology, organic chemistry, and microbiology to access bioactive natural products and their respective biosynthetic gene clusters from the soil. Will be responsible for using a range of techniques, including molecular biology, tissue culture, animal work (mouse), and chemistry.

Responsibilities

Responsibilities include:

• Design and execute independent and collaborative research projects.
• Maintain strong organizational practices, attention to detail, and accurate research
• Communicate effectively and work both independently and collaboratively
• Engage in scientific writing and dissemination activities, including opportunities to lead first-authored manuscripts and contribute to collaborative publications and literature reviews
• Perform related duties & responsibilities as assigned/requested

Qualifications

• REQUIRED QUALIFICATIONS: PhD in chemistry, biochemistry, microbiology, biology, or a related field
• Ability to independently conduct untargeted metabolomics studies and/or phylogenetic analyses of microbial communities in microbiome samples.
• Strong organization skills, attention to detail, and ability to maintain accurate records
• Excellent communication skills and the ability to work both independently and as part of a collaborative team in a fast-paced research environment

PREFERRED QUALIFICATIONS:

• Experience in multi-step natural product synthesis, medicinal chemistry, small molecule library development, compound characterization, and/or structure activity relationship optimization
• Experience in preparative and analytical chromatography and structural analysis of organic molecules
• Experience in peptide synthesis
• Experience with metabolite discovery and characterization
• The Rockefeller University is an equal opportunity employer – veterans/individuals with disabilities. Qualified applicants will receive consideration for employment without regard to characteristics protected by applicable local, state or federal law, including but not limited to disability and protected veteran status.
• The salary of the finalist selected for this role will be set based on various factors, including but not limited to organizational budgets, qualifications, experience, education, licenses, specialty, and training. The hiring range provided represents The Rockefeller University's good faith and reasonable estimate of the range of possible compensation at the time of posting.

Responsibilities

Responsibilities include:

• Design and execute independent and collaborative research projects.
• Maintain strong organizational practices, attention to detail, and accurate research
• Communicate effectively and work both independently and collaboratively
• Engage in scientific writing and dissemination activities, including opportunities to lead first-authored manuscripts and contribute to collaborative publications and literature reviews
• Perform related duties & responsibilities as assigned/requested

Qualifications

• REQUIRED QUALIFICATIONS: PhD in chemistry, biochemistry, microbiology, biology, or a related field
• Ability to independently conduct untargeted metabolomics studies and/or phylogenetic analyses of microbial communities in microbiome samples.
• Strong organization skills, attention to detail, and ability to maintain accurate records
• Excellent communication skills and the ability to work both independently and as part of a collaborative team in a fast-paced research environment

PREFERRED QUALIFICATIONS:

• Experience in multi-step natural product synthesis, medicinal chemistry, small molecule library development, compound characterization, and/or structure activity relationship optimization
• Experience in preparative and analytical chromatography and structural analysis of organic molecules
• Experience in peptide synthesis
• Experience with metabolite discovery and characterization
• The Rockefeller University is an equal opportunity employer – veterans/individuals with disabilities. Qualified applicants will receive consideration for employment without regard to characteristics protected by applicable local, state or federal law, including but not limited to disability and protected veteran status.
• The salary of the finalist selected for this role will be set based on various factors, including but not limited to organizational budgets, qualifications, experience, education, licenses, specialty, and training. The hiring range provided represents The Rockefeller University's good faith and reasonable estimate of the range of possible compensation at the time of posting.