(Contract) Research Technician, Pre-clinical Pharmacology

Contract length:

12 months

Hours:

40 hours/week

Location:

On-site 5 days/week in Boston (Fenway Area)

Manifold Bio is a platform biotechnology company pioneering AI-guided protein design and massively multiplexed in vivo screening to unlock tissue-targeted medicines and organism-scale models of living systems.

Using proprietary molecular barcoding technology, we screen hundreds of thousands of protein designs simultaneously in living systems, producing in vivo-validated datasets at a scale no one else can match. The datasets power our computational models, which leads to better drug designs, creating a flywheel that gets stronger with every campaign. Our team of protein engineers, biologists, and computational scientists works across this full stack to pursue programs both internally and with leading pharma companies.

Position

Manifold Bio is looking for an organized, motivated In-Vivo Research Technician to join our pharmacology team on a one-year contract. You will work alongside experienced researchers to prepare for and execute mouse studies supporting our internal drug discovery programs. This role is deliberately structured around training and growth. We are looking for someone with excellent organizational instincts, and genuine enthusiasm for learning the rest.

Dosing routes, blood collection, necropsy and tissue processing can all be taught, and we are committed to teaching them. For the right person, this contract is intended as a path toward a permanent Research Associate position.

• Required Qualifications
• Prepare and label tubes, cages and collection supplies ahead of each study
• Set up procedure rooms for dosing days and takedowns
• Hands-on experience with animal handling, including the ability to confidently scruff a mouse
• Comfort working with laboratory animals in a vivarium environment
• Tattoo and tail-mark mice; prepare and organize study cages
• Weigh animals and record data accurately
• Maintain study records in Benchling
• Help maintain lab and vivarium inventories
• Support necropsy and tissue collection (training provided)
• Process collected samples, primarily serum
• As time allows, assist with tissue weighing and lysis for downstream analysis
• Strong organizational skills and attention to detail
• Ability to follow written protocols and SOPs accurately
• A proactive approach — someone who plans ahead rather than reacting
• Genuine enthusiasm for learning new techniques, and a collaborative, team-first attitude

Preferred Qualifications

• Hands-on experience with animal handling, including the ability to confidently scruff a mouse
• Experience with SC, IV or PO dosing
• Submental blood collection
• Necropsy and tissue dissection
• Tissue lysis, nucleic acid extraction or other basic bench techniques
• Familiarity with Benchling or similar electronic lab notebooks
• We value different experiences and ways of thinking and believe the most talented teams are built by bringing together people of diverse cultures, genders, and backgrounds.