Sr. Clinical Trial Manager

Frontier Medicines is seeking two Sr. Clinical Trial Managers to support the day-to-day execution of our oncology clinical trials as they advance through clinical development. Working under the guidance of our Sr. Director, Clinical Operations, you will serve as a key operational contact for our CROs and trial sites, helping drive feasibility assessments, site selection, start-up, maintenance, and close-out.

This is a great opportunity for someone who wants hands-on ownership of trial execution at a growing, clinical-stage biotech, with direct exposure to program strategy and cross-functional leadership. This is a hybrid role based in our Boston, MA office, with an expectation of 2-3 days per week onsite, plus periodic travel to trial sites and CRO/vendor meetings as needed.

Requirements

• What will you be doing?
• ● Support day-to-day activities within one or more clinical trials, including country/site feasibility assessments, site selection, start-up, maintenance, and close-out.
• ● Serve as a key operational point of contact for CROs and trial sites, identifying and escalating potential issues as needed.
• ● Assist with oversight of CRO and vendor set-up, liaising with CROs to ensure timely study initiation.
• ● Review site-level regulatory documents (e.g., Informed Consent Forms, essential documents) and escalate to appropriate stakeholders as needed.
• ● Help ensure inspection readiness, TMF quality, and adherence to protocol and regulatory requirements.
• ● Proactively identify potential operational challenges and, in partnership with senior team members, propose mitigation plans to keep study execution on track.
• ● Assist with review of protocols, master template informed consent forms, case report forms, and other clinical study documents as needed.
• ● Monitor study performance metrics, timelines, and deliverables, and review CRO trip reports for trends and quality issues.
• ● Track study budgets and vendor invoices/change orders in partnership with Clinical Operations and Finance, flagging discrepancies as needed.
• ● Help maintain timely and accurate study registration and updates on ClinicalTrials.gov and other applicable registries.
• ● Coordinate Clinical Trial Team meetings and drive action item follow-up.
• ● Maintain clinical operations trackers, databases, and document repositories.
• ● Provide regular study updates to internal stakeholders and support enrollment, database lock, and study closeout activities.
• Traits we believe make a strong candidate: ● Bachelor's degree in a scientific, healthcare, or related field, or an RN, required.
• ● 5-7 years of Clinical Trial Manager/SCTM or Clinical Project Management experience, ideally supporting oncology clinical trials.
• ● Experience supporting oncology studies strongly preferred.
• ● Vendor and CRO management experience.
• ● Strong working knowledge of ICH-GCP guidelines and clinical trial regulations.
• ● Excellent organizational, problem-solving, and time management skills, with strong attention to detail.
• ● Strong written and verbal communication skills with a collaborative, team-oriented approach.
• ● Comfortable in a fast-paced, dynamic environment; a proactive, roll-up-your-sleeves mindset.
• ● Legally authorized to work in the United States.